December 6 - 10, 2010 at Atlantic City, New Jersey
The 66th Deming Conference on Applied Statistics
Sponsored by Metropolitan Section, ASQ and Biopharmaceutical Section, ASA
   
Abstract

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12/8/2010 (Wednesday) 1:00 PM - 4:00 PM

Session K: Clinical Trial Methodology: Case Studies

Dr. Karl E. Peace, Georgia Southern University

Moderator: Kalyan Ghosh
 
A clinical trial is a research study conducted to assess the utility of an intervention in volunteers. Interventions may be diagnostic, preventative or treatment in nature and may include drugs, biologics, medical devices or methods of screening. Interventions may also include procedures whose aim is to improve quality of life or to better understand how the intervention works in volunteers. Clinical trial methodology (CTM) comprises all methods required for the protection of participants in a clinical trial and all methods necessary to provide a valid inference about the objective of the trial. In short, CTM consists of all methods necessary to develop and conduct a quality clinical trial protocol and to provide quality data collection, biostatistical analyses and a clinical study report while maintaining the highest standards of ethics and excellence. Several landmark clinical trials from the presenter’s own experience that led to regulatory approval of drugs (e.g. reducing CHD risk, optimal treatment of DU, prevention of GU, and a parallel bioequivalence trial) will be reviewed from a case study approach with attention to CTM utilized

Karl E. Peace, Ph.D. is Senior Research Scientist, Professor of Biostatistics and the Georgia Cancer Coalition Distinguished Cancer Scholar in the Jiann-Ping Hsu College of Public


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